CK20 and p53 Immunohistochemical Staining Patterns in Urinary Bladder Specimens With Equivocal Atypia
نویسندگان
چکیده
منابع مشابه
Differential diagnosis of urothelial carcinoma in situ from non-neoplastic urothelia: Analysis of CK20, CD44, P53 and Ki67
Background: Flat urothelial lesions comprise a spectrum of morphologic changes ranging from reactive atypia to carcinoma in situ (CIS). Urothelial dysplasia and CIS are associated with the recurrence and progression of urothelial carcinoma. Distinguishing CIS and dysplasia from reactive atypia based on histolopathogical features alone is often difficult. Using different immunohistochemical mark...
متن کاملEvaluation of the prognostic value of CD117 and CK20 biomarkers in urinary bladder carcinoma
Background: Over-expression of CD117 and cytokeratin 20 (CK20) is seen in many malignancies. Given that few studies have been conducted regarding the role of these biomarkers in the etiology of bladder tumours, this study aimed to evaluate the prognostic value of CD117 and CK 20 biomarkers in the benign and malignant tumours of urinary bladder carcinoma. Methods: This case-control study was co...
متن کاملUtility of a dual immunostain cocktail comprising of p53 and CK20 to aid in the diagnosis of non-neoplastic and neoplastic bladder biopsies
BACKGROUND Distinction between non-neoplastic and neoplastic bladder lesions is therapeutically and prognostically important. Our objective is to describe the use of double immunohistochemistry (DIHC) for p53+CK20 as a tool for diagnosing neoplasia in bladder biopsies. METHODS p53+CK20 DIHC were examined in 38 reactive atypia, 10 dysplasia, 9 carcinoma in situ (CIS) and 7 invasive carcinoma (...
متن کاملdifferential diagnosis of urothelial carcinoma in situ from non-neoplastic urothelia: analysis of ck20, cd44, p53 and ki67
background: flat urothelial lesions comprise a spectrum of morphologic changes ranging from reactive atypia to carcinoma in situ (cis). urothelial dysplasia and cis are associated with the recurrence and progression of urothelial carcinoma. distinguishing cis and dysplasia from reactive atypia based on histolopathogical features alone is often difficult. using different immunohistochemical mark...
متن کاملClinico-Pathological Correlation of Urothelial Carcinoma of Urinary Bladder with P63 and CK20 Immunostain
Urinary bladder carcinoma is a common cancer in the Indian population in increasing incidence over the past few decades. Most of the tumours of the urinary bladder are urothelial carcinomas, comprising approximately 90% of all primary tumours of this organ. Urothelial carcinoma is one of the major causes of morbidity and mortality throughout the world and also in India. The objective is to asse...
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ژورنال
عنوان ژورنال: Archives of Pathology & Laboratory Medicine
سال: 2017
ISSN: 0003-9985,1543-2165
DOI: 10.5858/arpa.2016-0411-oa